Fig 1. Infection outcomes induced by strain UK1 and its codY mutant derivative.

Groups of mice (n = 10) were infected with spores of strain UK1 and its codY null mutant (UK1 codY, also known as LB-CD16) and were monitored for weight change at doses of 10⁵ spores per mouse (A) or 10⁴ spores per mouse (B). Weight changes between the two groups were analyzed by 2-way ANOVA. The p values were calculated based on the differences in weight changes between the mice infected with the wild-type strain and the mice infected with the codY null mutant over the entire time course of the experiment (days 0–9 for Fig 1A and days 0–7 for Fig 1B). The impact of these infections on mouse diarrhea and viability is listed in Table 1.