Skip to main content
. 2019 Jan 30;14(1):e0206896. doi: 10.1371/journal.pone.0206896

Fig 10. Impact of codY mutations on expression of the genes and biochemical intermediates of the BCAA biosynthesis pathway.

Fig 10

On the left side of the figure, the pathway from pyruvate to valine and leucine is shown. The genes that code for the various enzymes are in italics. The numbers in parentheses indicate the RPKMO ratios for each of the genes in the codY null mutant relative to wild-type and the concentrations of the various metabolites in the codY null mutant relative to the wild-type. The right side of the figure shows the results of metabolomics analysis for a panel of codY mutants relative to wild-type (the latter set at 1.0 for all metabolites). The pathway to valine is shown above the pathway to leucine. The asterisk associated with the concentration of leucine indicates that the concentration is actually the sum of leucine and isoleucine, which were not separated in this analysis. The double asterisk for 2- and 3-isopropylmalate indicates that 2.9 is the sum of the two inseparable isomers.