Summary of findings 7. Proportion of participants vomiting.
| IV paracetamol/propacetamol compared to placebo or other analgesics for postoperative pain | |||||
| Patient or population: patients with postoperative pain Settings: hospital Intervention: IV paracetamol/propacetamol Comparison: placebo or other analgesics | |||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | |
| Assumed risk | Corresponding risk | ||||
| Placebo or other analgesics | IV paracetamol/propacetamol | ||||
| Para/propacetamol vs placebo | 208 per 1000 | 145 per 1000 (118 to 181) | RR 0.7 (0.57 to 0.87) | 1414 (15 studies) | ⊕⊝⊝⊝ very low1,2,3,4 |
| Paracetamol vs placebo | 263 per 1000 | 168 per 1000 (134 to 210) | RR 0.64 (0.51 to 0.8) | 1037 (13 studies) | ⊕⊝⊝⊝ very low1,3,4 |
| Propacetamol vs placebo | 45 per 1000 | 74 per 1000 (34 to 158) | RR 1.62 (0.75 to 3.48) | 377 (3 studies) | ⊕⊕⊝⊝ low3,5 |
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: confidence interval; NNH = number needed to treat to harm; RR: risk ratio | |||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | |||||
1Majority of all individual studies had < 100 participants. 2Considerable unexplained heterogeneity exists between studies. 3Total # events < 300. 4Publication bias suspected in favor of a lower occurrence of vomiting in the paracetamol and/or propacetamol arm; NNH > 10. 5Wide confidence interval that includes no effect and appreciable benefit and/or harm.