1. Publication bias risk assessment: efficacy outcomes.

Comparison/outcome	Number of studies	Number of participants	n with outcome/total		% with outcome		Risk difference	NNT	Susceptibility to publication bias
			Active	Control	Active	Control
Comparison 1. Number of participants with > 50% pain relief over 4 hours
1 Paracetamol or propacetamol vs placebo	11	1149	250/687	72/462	36	16	0.23 (0.18 to 0.27)	5	1492
1.1 Paracetamol vs placebo	5	393	84/272	8/121	31	7	0.24 (0.17 to 0.31)	5	549
1.2 Propacetamol vs placebo	8	756	166/415	64/341	40	19	0.22 (0.17 to 0.27)	5	906
Comparison 2. Number of participants with > 50% pain relief over 6 hours
1 Paracetamol or propacetamol vs placebo	10	1143	200/708	42/435	28	10	0.18 (0.14 to 0.22)	6	913
1.1 Paracetamol vs placebo	6	532	109/364	14/168	30	8	0.22 (0.16 to 0.29)	5	637
1.2 Propacetamol vs placebo	6	611	91/344	28/267	26	10	0.15 (0.10 0.20)	7	305
2. Paracetamol or propacetamol vs NSAIDs	5	355	95/192	103/163	50	63	‐0.13 (‐0.23 to ‐0.03)	8*	107
Comparison 5. Number of participants requiring rescue medication
1 Paracetamol or propacetamol vs placebo	9	859	295/476	314/383	62	82	‐0.25 (‐0.30 to ‐0.19)	4	1289
1.1 Paracetamol vs placebo	6	655	267/376	249/279	71	89	‐0.22 (‐0.28 to ‐0.17)	5	785
1.2 Propacetamol vs placebo	3	204	31/100	65/104	31	62	‐0.32 (‐0.44 to ‐0.19)	4	449
Comparison 9. Global evaluation rated as good/satisfied or excellent/very satisfied
1 Paracetamol or propacetamol vs placebo	16	2015	787/1100	529/915	72	58	0.19 (0.15 to 0.23)	6	1816
1.1 Paracetamol vs placebo	9	876	355/508	207/368	70	56	0.24 (0.19 to 0.29)	5	1225
1.2 Propacetamol vs placebo	9	1139	432/592	322/547	73	59	0.15 (0.10 to 0.21)	7	569
2. Paracetamol or propacetamol vs NSAIDs	11	795	306/410	313/385	75	81	‐0.06 (‐0.11 to ‐4.81)	17*	NNT > 10

*NSAID superior