Comparison 1. Number of participants with > 50% pain relief over 4 hours.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Paracetamol or propacetamol vs placebo	11	1149	Risk Ratio (M‐H, Fixed, 95% CI)	2.53 [2.01, 3.19]
1.1 Paracetamol vs placebo	5	393	Risk Ratio (M‐H, Fixed, 95% CI)	4.80 [2.30, 10.00]
1.2 Propacetamol vs placebo	8	756	Risk Ratio (M‐H, Fixed, 95% CI)	2.19 [1.74, 2.77]
2 Paracetamol or propacetamol vs NSAIDs	5	353	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.86, 1.18]
2.1 Paracetamol vs NSAIDs	2	130	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.72, 1.13]
2.2 Propacetamol vs NSAIDs	3	223	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.86, 1.34]
3 Propacetamol vs opioids	1	61	Risk Ratio (M‐H, Fixed, 95% CI)	1.16 [0.85, 1.59]
4 Paracetamol vs propacetamol	3	361	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.77, 1.24]