Comparison 5. Number of participants requiring rescue medication.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Paracetamol or propacetamol vs placebo	9	859	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.64, 0.77]
1.1 Paracetamol vs placebo	6	655	Risk Ratio (M‐H, Fixed, 95% CI)	0.75 [0.69, 0.82]
1.2 Propacetamol vs placebo	3	204	Risk Ratio (M‐H, Fixed, 95% CI)	0.49 [0.35, 0.69]
2 Paracetamol or propacetamol vs NSAIDs	5	309	Risk Ratio (M‐H, Fixed, 95% CI)	1.19 [0.87, 1.63]
2.1 Paracetamol vs NSAIDs	2	120	Risk Ratio (M‐H, Fixed, 95% CI)	1.08 [0.59, 1.98]
2.2 Propacetamol vs NSAIDs	3	189	Risk Ratio (M‐H, Fixed, 95% CI)	1.23 [0.86, 1.77]
3 Propacetamol vs opioids	2	139	Risk Ratio (M‐H, Fixed, 95% CI)	1.83 [0.72, 4.64]
4 Paracetamol vs propacetamol	1	161	Risk Ratio (M‐H, Fixed, 95% CI)	1.33 [0.82, 2.17]