Comparison 12. Number of participants with serious adverse events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Paracetamol or propacetamol vs placebo	10	970	Risk Ratio (M‐H, Fixed, 95% CI)	1.12 [0.19, 6.59]
1.1 Paracetamol vs placebo	6	634	Risk Ratio (M‐H, Fixed, 95% CI)	1.12 [0.19, 6.59]
1.2 Propacetamol vs placebo	5	336	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 Paracetamol or propacetamol vs NSAIDs	9	798	Risk Ratio (M‐H, Fixed, 95% CI)	0.43 [0.11, 1.65]
2.1 Paracetamol vs NSAIDs	4	270	Risk Ratio (M‐H, Fixed, 95% CI)	1.0 [0.07, 15.26]
2.2 Propacetamol vs NSAIDs	5	528	Risk Ratio (M‐H, Fixed, 95% CI)	0.34 [0.07, 1.65]
3 Paracetamol or propacetamol vs opioids	3	191	Risk Ratio (M‐H, Fixed, 95% CI)	3.0 [0.13, 71.51]
3.1 Paracetamol vs opioids	1	50	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.2 Propacetamol vs opioids	2	141	Risk Ratio (M‐H, Fixed, 95% CI)	3.0 [0.13, 71.51]