Comparison 13. Number of participants withdrawing due to adverse events.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Paracetamol or propacetamol vs placebo	37	2654	Risk Ratio (M‐H, Fixed, 95% CI)	1.26 [0.56, 2.84]
1.1 Paracetamol vs placebo	27	1912	Risk Ratio (M‐H, Fixed, 95% CI)	1.25 [0.49, 3.17]
1.2 Propacetamol vs placebo	12	742	Risk Ratio (M‐H, Fixed, 95% CI)	1.29 [0.25, 6.68]
2 Paracetamol or propacetamol vs NSAIDs	24	1429	Risk Ratio (M‐H, Fixed, 95% CI)	1.15 [0.42, 3.12]
2.1 Paracetamol vs NSAIDs	19	1029	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.31, 3.22]
2.2 Propacetamol vs NSAIDs	5	400	Risk Ratio (M‐H, Fixed, 95% CI)	1.67 [0.22, 12.37]
3 Paracetamol or propacetamol vs opioids	6	505	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.01, 7.95]
3.1 Paracetamol vs opioids	2	254	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.2 Propacetamol vs opioids	4	251	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.01, 7.95]
4 Paracetamol vs ketamine	1	80	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]