Comparison 16. Individual adverse events: paracetamol or propacetamol vs placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Nausea	15	1267	Risk Ratio (M‐H, Fixed, 95% CI)	0.84 [0.73, 0.98]
1.1 Paracetamol vs placebo	13	1037	Risk Ratio (M‐H, Fixed, 95% CI)	0.77 [0.66, 0.90]
1.2 Propacetamol vs placebo	3	230	Risk Ratio (M‐H, Fixed, 95% CI)	1.62 [0.98, 2.69]
2 Vomiting	15	1414	Risk Ratio (M‐H, Fixed, 95% CI)	0.70 [0.57, 0.87]
2.1 Paracetamol vs placebo	13	1037	Risk Ratio (M‐H, Fixed, 95% CI)	0.64 [0.51, 0.80]
2.2 Propacetamol vs placebo	3	377	Risk Ratio (M‐H, Fixed, 95% CI)	1.62 [0.75, 3.48]
3 Nausea/vomiting	10	1064	Risk Ratio (M‐H, Fixed, 95% CI)	0.90 [0.74, 1.08]
3.1 Paracetamol vs placebo	4	191	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.57, 1.70]
3.2 Propacetamol vs placebo	6	873	Risk Ratio (M‐H, Fixed, 95% CI)	0.88 [0.72, 1.08]
4 Pruritus	7	618	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.60, 1.40]
4.1 Paracetamol vs placebo	5	320	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.64, 1.72]
4.2 Propacetamol vs placebo	3	298	Risk Ratio (M‐H, Fixed, 95% CI)	0.67 [0.29, 1.51]
5 Respiratory depression	11	1082	Risk Ratio (M‐H, Fixed, 95% CI)	0.77 [0.31, 1.92]
5.1 Paracetamol vs placebo	6	363	Risk Ratio (M‐H, Fixed, 95% CI)	0.28 [0.03, 2.65]
5.2 Propacetamol vs placebo	5	719	Risk Ratio (M‐H, Fixed, 95% CI)	0.99 [0.35, 2.80]
6 Sedation	10	566	Risk Ratio (M‐H, Fixed, 95% CI)	1.00 [0.66, 1.51]
6.1 Paracetamol vs placebo	6	341	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.42, 2.01]
6.2 Propacetamol vs placebo	4	225	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.65, 1.69]
7 Urinary retention	8	1050	Risk Ratio (M‐H, Fixed, 95% CI)	1.06 [0.68, 1.66]
7.1 Paracetamol vs placebo	5	373	Risk Ratio (M‐H, Fixed, 95% CI)	1.36 [0.28, 6.66]
7.2 Propacetamol vs placebo	3	677	Risk Ratio (M‐H, Fixed, 95% CI)	1.04 [0.65, 1.66]
8 Allergy/skin rash/local reaction	7	1131	Risk Ratio (M‐H, Fixed, 95% CI)	1.54 [0.61, 3.91]
8.1 Paracetamol vs placebo	4	370	Risk Ratio (M‐H, Fixed, 95% CI)	1.01 [0.24, 4.34]
8.2 Propacetamol vs placebo	4	761	Risk Ratio (M‐H, Fixed, 95% CI)	1.97 [0.57, 6.73]