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. 2016 May 23;2016(5):CD007126. doi: 10.1002/14651858.CD007126.pub3

Comparison 16. Individual adverse events: paracetamol or propacetamol vs placebo.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Nausea 15 1267 Risk Ratio (M‐H, Fixed, 95% CI) 0.84 [0.73, 0.98]
1.1 Paracetamol vs placebo 13 1037 Risk Ratio (M‐H, Fixed, 95% CI) 0.77 [0.66, 0.90]
1.2 Propacetamol vs placebo 3 230 Risk Ratio (M‐H, Fixed, 95% CI) 1.62 [0.98, 2.69]
2 Vomiting 15 1414 Risk Ratio (M‐H, Fixed, 95% CI) 0.70 [0.57, 0.87]
2.1 Paracetamol vs placebo 13 1037 Risk Ratio (M‐H, Fixed, 95% CI) 0.64 [0.51, 0.80]
2.2 Propacetamol vs placebo 3 377 Risk Ratio (M‐H, Fixed, 95% CI) 1.62 [0.75, 3.48]
3 Nausea/vomiting 10 1064 Risk Ratio (M‐H, Fixed, 95% CI) 0.90 [0.74, 1.08]
3.1 Paracetamol vs placebo 4 191 Risk Ratio (M‐H, Fixed, 95% CI) 0.99 [0.57, 1.70]
3.2 Propacetamol vs placebo 6 873 Risk Ratio (M‐H, Fixed, 95% CI) 0.88 [0.72, 1.08]
4 Pruritus 7 618 Risk Ratio (M‐H, Fixed, 95% CI) 0.92 [0.60, 1.40]
4.1 Paracetamol vs placebo 5 320 Risk Ratio (M‐H, Fixed, 95% CI) 1.05 [0.64, 1.72]
4.2 Propacetamol vs placebo 3 298 Risk Ratio (M‐H, Fixed, 95% CI) 0.67 [0.29, 1.51]
5 Respiratory depression 11 1082 Risk Ratio (M‐H, Fixed, 95% CI) 0.77 [0.31, 1.92]
5.1 Paracetamol vs placebo 6 363 Risk Ratio (M‐H, Fixed, 95% CI) 0.28 [0.03, 2.65]
5.2 Propacetamol vs placebo 5 719 Risk Ratio (M‐H, Fixed, 95% CI) 0.99 [0.35, 2.80]
6 Sedation 10 566 Risk Ratio (M‐H, Fixed, 95% CI) 1.00 [0.66, 1.51]
6.1 Paracetamol vs placebo 6 341 Risk Ratio (M‐H, Fixed, 95% CI) 0.92 [0.42, 2.01]
6.2 Propacetamol vs placebo 4 225 Risk Ratio (M‐H, Fixed, 95% CI) 1.05 [0.65, 1.69]
7 Urinary retention 8 1050 Risk Ratio (M‐H, Fixed, 95% CI) 1.06 [0.68, 1.66]
7.1 Paracetamol vs placebo 5 373 Risk Ratio (M‐H, Fixed, 95% CI) 1.36 [0.28, 6.66]
7.2 Propacetamol vs placebo 3 677 Risk Ratio (M‐H, Fixed, 95% CI) 1.04 [0.65, 1.66]
8 Allergy/skin rash/local reaction 7 1131 Risk Ratio (M‐H, Fixed, 95% CI) 1.54 [0.61, 3.91]
8.1 Paracetamol vs placebo 4 370 Risk Ratio (M‐H, Fixed, 95% CI) 1.01 [0.24, 4.34]
8.2 Propacetamol vs placebo 4 761 Risk Ratio (M‐H, Fixed, 95% CI) 1.97 [0.57, 6.73]