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. 2016 May 23;2016(5):CD007126. doi: 10.1002/14651858.CD007126.pub3

Comparison 17. Individual adverse events: paracetamol or propacetamol vs NSAIDs.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Nausea 11 856 Risk Ratio (M‐H, Fixed, 95% CI) 1.07 [0.90, 1.28]
1.1 Paracetamol vs NSAIDs 8 424 Risk Ratio (M‐H, Fixed, 95% CI) 0.98 [0.74, 1.31]
1.2 Propacetamol vs NSAIDs 3 432 Risk Ratio (M‐H, Fixed, 95% CI) 1.15 [0.92, 1.44]
2 Vomiting 11 856 Risk Ratio (M‐H, Fixed, 95% CI) 1.17 [0.89, 1.55]
2.1 Paracetamol vs NSAIDs 8 424 Risk Ratio (M‐H, Fixed, 95% CI) 1.14 [0.77, 1.68]
2.2 Propacetamol vs NSAIDs 3 432 Risk Ratio (M‐H, Fixed, 95% CI) 1.21 [0.81, 1.81]
3 Nausea/vomiting 8 408 Risk Ratio (M‐H, Fixed, 95% CI) 1.11 [0.62, 1.97]
3.1 Paracetamol vs NSAIDs 4 208 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.42, 2.39]
3.2 Propacetamol vs NSAIDs 4 200 Risk Ratio (M‐H, Fixed, 95% CI) 1.2 [0.55, 2.60]
4 Pruritus 8 558 Risk Ratio (M‐H, Fixed, 95% CI) 0.96 [0.69, 1.34]
4.1 Paracetamol vs NSAIDs 5 286 Risk Ratio (M‐H, Fixed, 95% CI) 1.07 [0.75, 1.51]
4.2 Propacetamol vs NSAIDs 3 272 Risk Ratio (M‐H, Fixed, 95% CI) 0.77 [0.37, 1.60]
5 Respiratory depression 9 510 Risk Ratio (M‐H, Fixed, 95% CI) 0.75 [0.17, 3.26]
5.1 Paracetamol vs NSAIDs 8 470 Risk Ratio (M‐H, Fixed, 95% CI) 0.75 [0.17, 3.26]
5.2 Propacetamol vs NSAIDs 1 40 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 Sedation 6 278 Risk Ratio (M‐H, Fixed, 95% CI) 2.6 [0.63, 10.75]
6.1 Paracetamol vs NSAIDs 4 208 Risk Ratio (M‐H, Fixed, 95% CI) 1.0 [0.07, 14.90]
6.2 Propacetamol vs NSAIDs 2 70 Risk Ratio (M‐H, Fixed, 95% CI) 3.67 [0.63, 21.22]
7 Urinary retention 6 390 Risk Ratio (M‐H, Fixed, 95% CI) 1.09 [0.51, 2.32]
7.1 Paracetamol vs NSAIDs 4 178 Risk Ratio (M‐H, Fixed, 95% CI) 0.98 [0.24, 4.02]
7.2 Propacetamol vs NSAIDs 2 212 Risk Ratio (M‐H, Fixed, 95% CI) 1.14 [0.47, 2.78]
8 Allergy/skin rash/local reaction 8 399 Risk Ratio (M‐H, Fixed, 95% CI) 0.73 [0.24, 2.26]
8.1 Paracetamol vs NSAIDs 6 290 Risk Ratio (M‐H, Fixed, 95% CI) 1.03 [0.26, 4.02]
8.2 Propacetamol vs NSAIDs 2 109 Risk Ratio (M‐H, Fixed, 95% CI) 0.34 [0.04, 3.16]