Comparison 18. Individual adverse events: paracetamol or propacetamol vs opioids.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Nausea	6	545	Risk Ratio (M‐H, Fixed, 95% CI)	0.40 [0.24, 0.65]
1.1 Paracetamol vs opioids	4	438	Risk Ratio (M‐H, Fixed, 95% CI)	0.31 [0.17, 0.56]
1.2 Propacetamol vs opioids	2	107	Risk Ratio (M‐H, Fixed, 95% CI)	0.79 [0.32, 1.91]
2 Vomiting	5	495	Risk Ratio (M‐H, Fixed, 95% CI)	0.30 [0.12, 0.72]
2.1 Paracetamol vs opioids	3	388	Risk Ratio (M‐H, Fixed, 95% CI)	0.25 [0.08, 0.71]
2.2 Propacetamol vs opioids	2	107	Risk Ratio (M‐H, Fixed, 95% CI)	0.51 [0.10, 2.62]
3 Nausea/vomiting	1	30	Risk Ratio (M‐H, Fixed, 95% CI)	0.5 [0.15, 1.64]
3.1 Propacetamol vs opioids	1	30	Risk Ratio (M‐H, Fixed, 95% CI)	0.5 [0.15, 1.64]
4 Pruritus	3	157	Risk Ratio (M‐H, Fixed, 95% CI)	0.55 [0.21, 1.43]
4.1 Paracetamol vs opioids	1	50	Risk Ratio (M‐H, Fixed, 95% CI)	1.5 [0.27, 8.22]
4.2 Propacetamol vs opioids	2	107	Risk Ratio (M‐H, Fixed, 95% CI)	0.34 [0.10, 1.19]
5 Respiratory depression	1	50	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
5.1 Paracetamol vs opioids	1	50	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
6 Sedation	3	354	Risk Ratio (M‐H, Fixed, 95% CI)	0.10 [0.03, 0.34]
6.1 Paracetamol vs opioids	3	354	Risk Ratio (M‐H, Fixed, 95% CI)	0.10 [0.03, 0.34]