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. 2016 May 23;2016(5):CD007126. doi: 10.1002/14651858.CD007126.pub3

Delbos 1995.

Methods Randomized, double‐blind, placebo‐controlled
Medications administered in the recovery room
Participants Type of surgery: knee ligamentoplasty
Propacetamol group
Entered/completing: 30/29
Age (mean, SD): 25.5 ± 5.6
Sex (male, %): 97
Placebo group
Entered/completing: 30/28
Age (mean, SD): 26.3 ± 5.8
Sex (male, %): 90
Interventions Intervention: 2 g propacetamol in 125 ml 5% dextrose over 15 min
Placebo: 125 ml 5% dextrose
Outcomes Opioid consumption (morphine via PCA)
Pain intensity (VAS 0 to 100 and 5‐point VRS) and derived summary measures
Global efficacy (5‐point VRS)
Source of funding Not reported
Were treatment groups comparable at baseline? Yes: demographics, duration of surgery
Details of preoperative pain Not reported
Notes
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Not described
Allocation concealment (selection bias) Unclear risk Not described
Blinding (performance bias and detection bias) 
 All outcomes Unclear risk Not described
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Data presented for some outcomes from all participants, but for other outcomes from only those apparently completing the study
Selective reporting (reporting bias) Low risk All outcomes from Methods section reported in Results section
Size High risk Fewer than 50 participants per arm of the study (30 propacetamol, 30 placebo)