Delbos 1995.

Methods	Randomized, double‐blind, placebo‐controlled Medications administered in the recovery room
Participants	Type of surgery: knee ligamentoplasty Propacetamol group Entered/completing: 30/29 Age (mean, SD): 25.5 ± 5.6 Sex (male, %): 97 Placebo group Entered/completing: 30/28 Age (mean, SD): 26.3 ± 5.8 Sex (male, %): 90
Interventions	Intervention: 2 g propacetamol in 125 ml 5% dextrose over 15 min Placebo: 125 ml 5% dextrose
Outcomes	Opioid consumption (morphine via PCA) Pain intensity (VAS 0 to 100 and 5‐point VRS) and derived summary measures Global efficacy (5‐point VRS)
Source of funding	Not reported
Were treatment groups comparable at baseline?	Yes: demographics, duration of surgery
Details of preoperative pain	Not reported
Notes	—
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not described
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Data presented for some outcomes from all participants, but for other outcomes from only those apparently completing the study
Selective reporting (reporting bias)	Low risk	All outcomes from Methods section reported in Results section
Size	High risk	Fewer than 50 participants per arm of the study (30 propacetamol, 30 placebo)