Eremenko 2008.

Methods	Randomized, blinded, placebo‐controlled Medications administered 30 min before extubation
Participants	Type of surgery: coronary bypass surgery Paracetamol group Entered/completing: 22/? Age (mean, SD): unclear Sex (male, %): 77 Placebo group Entered/completing: 23/? Age (mean, SD): unclear Sex (male, %): 73
Interventions	Intervention: paracetamol 1 g/100 ml IV (every 6 h x 4 doses) Placebo: 100 ml normal saline
Outcomes	Inspiratory volume Pain intensity (VRS) AEs not reported All other outcomes described over duration of study (18 h)
Source of funding	Not reported
Were treatment groups comparable at baseline?	Yes: demographics
Details of preoperative pain	Not reported
Notes	Russian language study
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Described as blinded, but no mention of whether single‐ or double‐blinded
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Not described
Selective reporting (reporting bias)	Unclear risk	Not described
Size	High risk	Fewer than 50 participants per arm of the study (22 paracetamol, 23 placebo)