Kampe 2006.

Methods	Randomized, double‐blind, active‐controlled Medications administered 30 min before the end of surgery
Participants	Type of surgery: breast cancer (breast conserving or total mastectomy, balanced between groups) Propacetamol group Entered/completing: 20/20 Age (mean, SD): 52 ± 10.2 Sex (male, %): 0 Dipyrone group Entered/completing: 20/20 Age (mean, SD): 55.9 ± 8.7 Sex (male, %): 0
Interventions	Intervention: 1 g propacetamol in 100 ml solution over 15 min Control: 1 g dipyrone
Outcomes	Pain intensity at rest and on coughing (VAS) Opioid consumption (piritramide via PCA) Patient satisfaction (categorical)
Source of funding	In part supported by a grant from BristoΙ‐Myers Squibb GmbFΙ, München, Germany, with publication support provided by the Department of Anaesthesiology, University of Cologne
Were treatment groups comparable at baseline?	Yes: demographics, type of procedure
Details of preoperative pain	Not reported
Notes	—
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomization was based on a computer‐generated code
Allocation concealment (selection bias)	Low risk	Randomization results were sealed in sequentially numbered, opaque envelopes
Blinding (performance bias and detection bias) All outcomes	Low risk	The infusions were made to look identical; participants and investigators were blinded to the study treatment
Incomplete outcome data (attrition bias) All outcomes	Low risk	"The data for all patients were eligible for statistical analysis."
Selective reporting (reporting bias)	Low risk	All outcomes from Methods section reported in Results section
Size	High risk	Fewer than 50 participants per arm of the study (20 propacetamol, 20 dipyrone)