Kemppainen 2006.
Methods | Randomized, double‐blind, placebo‐controlled Medications administered at completion of surgery over 15 min |
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Participants | Type of surgery: endoscopic sinus Paracetamol group Entered/completing: 36/36 Age (mean, SD): not reported Sex (male, %): not reported Placebo group Entered/completing: 38/38 Age (mean, SD): not reported Sex (male, %): not reported |
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Interventions | Intervention: paracetamol 1 g IV Placebo: 100 ml normal saline |
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Outcomes | Pain intensity (NRS) Time to rescue medication Opioid consumption (oxycodone) |
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Source of funding | Not reported | |
Were treatment groups comparable at baseline? | No details | |
Details of preoperative pain | Not reported | |
Notes | — | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Computer‐generated randomization |
Allocation concealment (selection bias) | Low risk | Opaque envelope method |
Blinding (performance bias and detection bias) All outcomes | Low risk | The nurse preparing the infusions did not participate in the study. Preparation of infusions of identical volumes (100 ml) to assure blinding. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | "All the patients asked agreed to participate and there were no dropouts during the study". |
Selective reporting (reporting bias) | Low risk | All outcomes from Methods section reported in Results section |
Size | High risk | Fewer than 50 participants per arm of the study (36 paracetamol, 38 placebo) |