Moller 2005a.

Methods	Randomized, double‐dummy, placebo and active‐controlled Medication administered when baseline pain reached moderate‐to‐severe intensity within 4 h after surgery
Participants	Type of surgery: third molar extraction Paracetamol group Entered/completing: 51/51 Age (mean, SD): 24.5 ± 2.9 Sex (male, %): 69 Propacetamol group Entered/completing: 51/51 Age (mean, SD): 24.3 ± 3.6 Sex (male, %): 57 Placebo group Entered/completing: 50/50 Age (mean, SD): 24.5 ± 2.8 Sex (male, %): 68
Interventions	Intervention: IV paracetamol 1 g Control: propacetamol 2 g Placebo: 100 ml saline, or 100 ml solution (double‐dummy)
Outcomes	Primary outcome: pain relief (VRS) Maximum pain relief, time of maximum pain relief, time to onset of pain relief, TOTPAR Pain intensity (VRS, VAS) and derived summary measures Time to rescue medication (oral ibuprofen 400 mg) Global evaluation (categorical)
Source of funding	Supported by the Bristol‐Myers Squibb Company
Were treatment groups comparable at baseline?	Yes: demographics and baseline postoperative pain
Details of preoperative pain	Participants with other painful physical conditions were excluded
Notes	Propacetamol and paracetamol were compared to placebo and then propacetamol was compared to paracetamol
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Treatments were allocated according to block randomization (each block, n = 6)
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Low risk	Double‐dummy technique employed
Incomplete outcome data (attrition bias) All outcomes	Low risk	"Treatments were randomized among 152 patients. No patients withdrew from the study and all patients were evaluated for efficacy and safety".
Selective reporting (reporting bias)	Low risk	All outcomes from Methods section reported in Results section
Size	Unclear risk	50 to 199 participants per arm of the study (51 paracetamol, 51 propacetamol, 50 placebo)