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. 2016 May 23;2016(5):CD007126. doi: 10.1002/14651858.CD007126.pub3

Siddik 2001.

Methods Randomized, double‐blind, double‐dummy, placebo‐ and active‐controlled
Medications administered immediately after surgery
Participants Type of surgery: cesarean delivery
Propacetamol group
Entered/completing: 20/20
Age (mean, SD): 31 ± 4.6
Sex (male, %): 0
Diclofenac group
Entered/completing: 20/20
Age (mean, SD): 31.4 ± 6
Sex (male, %): 0
Placebo group
Entered/completing: 20/20
Age (mean, SD): 30.6 ± 5.1
Sex (male, %): 0
Interventions Intervention: 2 g propacetamol
Control: 100 mg rectal diclofenac
Control: combination of 100 mg rectal diclofenac and 2 g propacetamol (not included in our analysis)
Placebo: double‐dummy, exact details not described
Outcomes Opioid consumption (morphine via PCA)
Pain intensity at rest and on coughing (VAS 0 to 10)
Global assessment (categorical, at 24 h)
Source of funding Not reported
Were treatment groups comparable at baseline? Yes: age, weight, height, parity, and gestationaΙ age
Details of preoperative pain Not reported
Notes
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Random number table
Allocation concealment (selection bias) Unclear risk Patients and staff were unaware of the patients' group assignment
Blinding (performance bias and detection bias) 
 All outcomes Low risk "to ensure blinding of both the parturients and the anaesthesiologist, patients in all groups received both an IV injection and a suppository during the same period"
Incomplete outcome data (attrition bias) 
 All outcomes Low risk From 80 patients one was excluded due to technical problems of the PCA device. Data obtained from the 79 remaining patients were used for the analysis of all outcomes and time points.
Selective reporting (reporting bias) Low risk All outcomes from Methods section reported in Results section
Size High risk Fewer than 50 participants per arm of the study (20 propacetamol, 20 diclofenac, 20 placebo)