Unal 2013.

Methods	Administration of IV paracetamol versus IV dexketoprofen versus placebo during incision closure
Participants	Type of surgery: total abdominal hysterectomy Paracetamol group Entered/completing: 21/20 Age (mean, SD): 48.1 ± 3.6 Sex (male, %): 0 Dexketoprofen group Entered/completing: 22/20 Age (mean, SD): 47.7 ± 5.9 Sex (male, %): 0 Placebo group Entered/completing: 21/20 Age (mean, SD): 48.1 ± 4.5 Sex (male, %): 0
Interventions	Paracetamol 1 g/100 ml in 15 min IV infusion, then every 6 h for 24 h Dexketoprofen: 50 mg in 100 ml 15 min IV infusion, then every 8 h for 24 h Placebo: normal saline 100 ml 15 min IV infusion, then every 6 h for 24 h
Outcomes	Primary: differences in cumulative 24 h morphine consumption Secondary: VAS pain scores, adverse events, patient satisfaction
Source of funding	None
Were treatment groups comparable at baseline?	Yes: weight, height, BMI, ASA 1/2, anesthesia duration, surgery duration
Details of preoperative pain	Participants with preoperative pain or regular analgesic use excluded
Notes	—
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated block random allocation
Allocation concealment (selection bias)	Low risk	Sealed, opaque envelopes
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Unblinded person preparing drugs, blinded person assessed outcomes. Unclear if the solutions looked the same. Drug administration frequency different among groups (3 versus four times daily), so blinding might have been compromised
Incomplete outcome data (attrition bias) All outcomes	Low risk	Number of dropouts low, evenly distributed among groups and reasons for dropout do not appear to be related to treatment
Selective reporting (reporting bias)	Unclear risk	Incomplete description of methodology for patient satisfaction assessment and incomplete presentation of data
Size	High risk	Fewer than 50 participants per arm of the study (21 paracetamol, 22 dexketoprofen, 21 placebo)