Vuilleumier 1998.

Methods	Randomized, double‐blind, active‐controlled Medications administered at the end of anesthesia
Participants	Type of surgery: various elective Propacetamol group Entered/completing: 40/38 Age (mean, SD): 39 ± 13 Sex (male, %): 47 Morphine group Entered/completing: 40/39 Age (mean, SD): 39 ± 14 Sex (male, %): 49
Interventions	Intervention: 30 mg/kg propacetamol in 150 ml dextrose 5% over 15 min Control: 0.2 mg/kg morphine IV
Outcomes	Number of patients requiring rescue analgesia (repeat dose of intervention) Pain intensity (VAS) Vigilance (trailmaking test)
Source of funding	UPSA Laboratories supplied drugs and covered logistical expenses of study
Were treatment groups comparable at baseline?	Yes: demographics, duration of anesthesia, type of surgery
Details of preoperative pain	Patients taking opioids were excluded
Notes	French language paper
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not described
Allocation concealment (selection bias)	Unclear risk	Not described
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Solutions prepared by third party, but unclear if they appeared identical
Incomplete outcome data (attrition bias) All outcomes	Low risk	From the 80 patients 3 were withdrawn. All the remaining 77 patients were included in efficacy analyses.
Selective reporting (reporting bias)	Low risk	All outcomes from Methods section reported in Results section
Size	High risk	Fewer than 50 participants per arm of the study (40 propacetamol, 40 morphine)