Study characteristics

Eligibility criteria (insert eligibility criteria for each characteristic as defined in the Protocol)

Yes

No

Unclear

Location in text (pg & ¶/fig/table)

Type of study

Randomized controlled trial

Controlled clinical trial

Cluster‐randomized trials

Participants

Adult patients (18 years of age or older) undergoing mechanical ventilation in an intensive care unit for longer than 24 hours

Types of intervention

BIS monitoring used

Sedation protocol used

Clinical method used to assess levels of sedation (clinical judgement or specific clinical sedation scoring tool) in the control arm with or without use of a titration protocol

Types of outcome measures

Intensive care unit (ICU) length of stay

Duration of mechanical ventilation

Longer‐term functional outcomes as reported by study authors

INCLUDE

EXCLUDE

Reason for exclusion

Notes: