Ou 2016.

Methods	Prospective randomized trial
Participants	60 adults (18‐65 years) mechanically ventilated for more than 48 hours in the induction, maintenance and recovery phase of sedation.
Interventions	BIS monitoring versus Sedation Agitation Scale (SAS). Details of sedation protocol not reported. Target BIS score 60‐70. Target SAS grade 3‐4.
Outcomes	Primary outcome in the induction phase was haemodynamic changes and in the maintenance and recovery phase was total dose of sedative used. In the induction phase SAS monitoring was associated with more stable haemodynamics (less hypotension and bradycardia). In the maintenance and recovery phase, BIS resulted in a marked reduction in the total dose of propofol and fentanyl but higher use of midazolam. Secondary outcomes (ICU mortality, ICU LOS, length of mechanical ventilation and serious adverse events) were similar between two groups.
Notes	Study only published as an abstract, not enough data provided for analysis. No contact details were provided for authors. Publishers when contacted did not provide authors' contact details.

BIS = Bispectral index; ICU= intensive care unit; LOS = length of stay