Campbell 2016.

Methods	Design: prospective, RCT Blinding: research associates blinded, participants and personnel unblinded, allocation concealed Dates: April 2006 to April 2010
Participants	n = 986 Included: adults (aged > 16 years) requiring PSA Excluded: critically ill people or people unable to give consent Location: emergency department, tertiary care university hospital, Canada
Interventions	Control (n = 501) Standard monitoring (cardiac monitoring, blood pressure monitoring, pulse oximetry) Intervention (n = 485) Standard monitoring (as above) and end‐tidal capnography (measured every 5 seconds or absence of waveform at any time)
Outcomes	Primary Oxygen desaturation (< 90% SpO2 for > 30 seconds) Airway interventions (airway repositioning manoeuvre, positive pressure ventilation, oral/nasal airway placement, endotracheal intubation)* Secondary Hypotension (SBP < 100 mmHg or < 85 mmHg if baseline < 100 mmHg) Sedation time (time from first dose of drug administration to commencement of procedure Recovery time (time from end of procedure to cessation of monitoring) Vomiting
Funding sources	Research grant from government organization (Capital Health Research Fund, Halifax, Nova Scotia, Canada)
Declarations of interest	No authors declared any actual or potential conflicts of interest.
Notes	* Published data for airway interventions was continuous. Dichotomous data obtained by contacting authors.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomly assigned to each group by research associates (blinded) using computer‐generated randomization.
Allocation concealment (selection bias)	Low risk	Allocation concealed using opaque white envelopes.
Blinding of participants and personnel (performance bias) All outcomes	High risk	Unblinded participants and personnel.
Blinding of outcome assessment (detection bias) All outcomes	High risk	Unblinded outcome assessment.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No data excluded, all data included in analysis.
Selective reporting (reporting bias)	Unclear risk	All participants accounted for. Study was not enrolled in a trial registry and thus modifications to the study methods could not be assessed.
Other bias	Low risk	Funding: supported by an independent government grant.