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. 2017 Jul 7;2017(7):CD006396. doi: 10.1002/14651858.CD006396.pub4

2. Assessment of quality of evidence (GRADE).

Comparison N Studies 1. RoB? 2. Inconsistent? 3. Indirect? 4. Imprecise? 5. Pub bias? 6. Large ES? 7. DR? 8. Opp Conf Qualitya
Outcome noise
Legislation vs no legislation 1 ITS yes 1 study no no 1 study yes no no very low (1)
One HPD vs another HPD 1 RCT 4 CBA 2 yes no no no not shown no no no low (1)
HPD+Instruction vs HPD‐instruction 2 RCT 2 no no no yes not shown na na na moderate (4)
Information vs no information 1 RCT (2 arms) 1 yes 1 study no yes 1 study na na na low (1, 4)
Outcome hearing loss
One HPD vs another HPD (TTS) 2 CBA                 no data
Muffs vs plugs 2 CBA 2 yes no no yes not shown no no no very low (1,4)
Frequent HPD vs less frequent use 1 CBA 1 yes 1 study no yes 1 study no no no very low (1)
HLPP vs audiometry 1 RCT 1 yes 1 study no no 1 study na na na moderate (1)
HLPP+exposure information vs HLPP‐information 1 CBA 1 yes 1 study no yes 1 study no no no very low (1,4)
Frequent HPD in HLPP vs less 5 CBA 5 yes no no yes not shown no no no very low (1,4)
HLPP vs no exposure 7 CBA 7 yes no no yes not shown no no no very low (1,4)
Follow‐up vs no follow‐up 1 CBA 1 yes 1 study no yes 1 study no no no very low (1,4)
HLPP+long shifts vs HLPP normal 1 CBA 1 yes 1 study no yes 1 study no no no very low (1,4)

1‐5 Reasons for downgrading: 1. Risk of bias/Limitations in study design 2. Inconsistency between studies. 3. Indirectness of PICO 4. Imprecision of the results 5. Publication bias. 6‐8 Reasons for upgrading: 6. Large effect size. 7. Dose‐repsonse relationship 8. Confounding opposes the direction of the effect;
 na= not applicable; 1 study = only one study available and impossible to assess consistency or publication bias

aFinal grading of quality of evidence, between brackets domain that led to down/upgrading the quality.