7. Risk of non‐ocular adverse effects.

Study ID	Comparison	Type of complication	Results
Aminocaproic acid
Kraft 1987	Systemic aminocaproic acid vs placebo	Nausea	Drug group: 8 of 24; placebo group 1 of 25
Kutner 1987	Systemic aminocaproic acid vs placebo	Nausea or vomiting	Drug group: 6 of 21; placebo group: 0 of 13
		Lightheadedness	Drug group: 7 of 21; placebo group: 1 of 13
		Systemic hypotension	Drug group: 4 of 21; placebo group: 1 of 13
		Total complications	Drug group: 10 of 21; placebo group: 1 of 13
McGetrick 1983	Systemic aminocaproic acid vs placebo	Nausea or vomiting	Drug group: 6 of 28; placebo group: 0 of 20
		Diarrhea	Drug group: 2 of 28; placebo group: 0 of 20
		Muscle cramps	Drug group: 1 of 28; placebo group: 0 of 20
Pieramici 2003	Topical aminocaproic acid vs placebo	Systemic hypotension	Drug group: 3 of 24; placebo group: 3 of 27
Crouch 1997	Systemic vs topical aminocaproic acid	Dizziness, nausea, vomiting	Oral group: 5 of 29; topical group: 1 of 35
Palmer 1986	Low‐dose vs standard‐dose systemic aminocaproic acid	Nausea or vomiting	Low‐dose group: 5 of 25; standard‐dose group: 9 of 33
		Dizziness and hypotension	Low‐dose group: 0 of 25; standard‐dose group: 5 of 33
		Syncope	Low‐dose group: 0 of 25; standard‐dose group: 2 of 33
		Diarrhea	Low‐dose group: 1 of 25; standard‐dose group: 0 of 33
		Rash or pruritis	Low‐dose group: 1 of 25; standard‐dose group: 2 of 33
		Hot flashes	Low‐dose group: 1 of 25; standard‐dose group: 0 of 33
		Dry mouth or nose	Low‐dose group: 1 of 25; standard‐dose group: 0 of 33
Farber 1991	Systemic aminocaproic acid vs oral prednisone	Any adverse event	Aminocaproic acid group: 0 of 56; prednisone group: 0 of 56
Tranexamic acid
Welsh 1983	Tranexamic acid vs placebo	Nausea	Drug group: 1 of 19; placebo group: 0 of 20
Rahmani 1999	Tranexamic acid vs placebo	Nausea	Drug group: 0 of 80; placebo group: 0 of 80
Aminomethylbenzoic acid
Liu 2002	Systemic aminomethylbenzoic acid vs placebo	Nausea and vomiting	Drug group: 7 of 60; placebo group: NR

NR: not reported.