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. 2019 Jan 14;2019(1):CD005431. doi: 10.1002/14651858.CD005431.pub4

Bedrossian 1974.

Methods Study design: Quasi‐randomized controlled series.
Exclusions after allocation: None.
Losses to follow‐up: None.
Intention‐to‐treat: All participants were analyzed in the group to which they were assigned.
Sample size calculations: Not reported.
Participants Country: USA.
Dates: Not reported.
Number allocated: 58 consecutive patients alternately assigned to treatment group after classification based on the size of initial hyphema.
Age: Not reported.
Sex: Not reported.
Race: Not reported.
Sickle cell disease: Not reported.
Participants appeared to be balanced with respect to baseline characteristics.
Inclusion criteria: Non‐total traumatic hyphema.
Interventions Cycloplegics (n = 28): 1% atropine ointment.
Miotics (n = 30): 2% pilocarpine ointment (or eserine ointment).
Treatment for both groups included:

  1. topical anesthetic if needed;

  2. bed rest;

  3. head of bed elevated 30° to 90°;

  4. binocular patching or pinhole glasses;

  5. no reading or watching television;

  6. metal shield over injured eye;

  7. soft, non‐chew diet;

  8. laxatives;

  9. room with other individuals; and

  10. sedation.
Outcomes Primary outcome: Time to resolution of primary hemorrhage.
Secondary outcomes:

  1. Risk of secondary hemorrhage

  2. Risk of iridodialysis


Follow‐up: Days 1 to 7.
Notes Funding source not reported.
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) High risk Allocation was not randomized: participants alternately assigned to treatment groups based on the blood level in the anterior chamber.
Allocation concealment (selection bias) High risk Allocation was assigned on an alternate basis.
Blinding (performance bias and detection bias) 
 Participants High risk Masking was not reported.
Blinding (performance bias and detection bias) 
 Personnel and outcome assessors High risk Masking was not reported.
Incomplete outcome data (attrition bias) 
 Primary outcome Low risk All participants were analyzed in the group to which they had been assigned.
Incomplete outcome data (attrition bias) 
 Secondary outcomes Low risk All participants were analyzed in the group to which they had been assigned.
Selective reporting (reporting bias) Low risk Reported results for primary and secondary outcomes
Other bias Low risk No other sources of potential bias were identified.