Bedrossian 1974.
Methods | Study design: Quasi‐randomized controlled series. Exclusions after allocation: None. Losses to follow‐up: None. Intention‐to‐treat: All participants were analyzed in the group to which they were assigned. Sample size calculations: Not reported. |
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Participants | Country: USA. Dates: Not reported. Number allocated: 58 consecutive patients alternately assigned to treatment group after classification based on the size of initial hyphema. Age: Not reported. Sex: Not reported. Race: Not reported. Sickle cell disease: Not reported. Participants appeared to be balanced with respect to baseline characteristics. Inclusion criteria: Non‐total traumatic hyphema. |
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Interventions | Cycloplegics (n = 28): 1% atropine ointment. Miotics (n = 30): 2% pilocarpine ointment (or eserine ointment). Treatment for both groups included:
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Outcomes | Primary outcome: Time to resolution of primary hemorrhage. Secondary outcomes:
Follow‐up: Days 1 to 7. |
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Notes | Funding source not reported. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | High risk | Allocation was not randomized: participants alternately assigned to treatment groups based on the blood level in the anterior chamber. |
Allocation concealment (selection bias) | High risk | Allocation was assigned on an alternate basis. |
Blinding (performance bias and detection bias) Participants | High risk | Masking was not reported. |
Blinding (performance bias and detection bias) Personnel and outcome assessors | High risk | Masking was not reported. |
Incomplete outcome data (attrition bias) Primary outcome | Low risk | All participants were analyzed in the group to which they had been assigned. |
Incomplete outcome data (attrition bias) Secondary outcomes | Low risk | All participants were analyzed in the group to which they had been assigned. |
Selective reporting (reporting bias) | Low risk | Reported results for primary and secondary outcomes |
Other bias | Low risk | No other sources of potential bias were identified. |