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. 2019 Jan 14;2019(1):CD005431. doi: 10.1002/14651858.CD005431.pub4

Liu 2002.

Methods Study design: Randomized clinical trial.
Exclusions after randomization: None.
Losses to follow‐up: None.
Intention‐to‐treat: All participants were analyzed in the group to which they had been randomly assigned.
Sample size calculations: Not reported.
Participants Country: China.
Dates: December 1997 to December 2000.
Number randomized: 92: 60 to aminomethylbenzoic acid, 32 to control.
Age: Mean age: aminomethylbenzoic acid 32.7 ± 11.25 years, control 33.4 ± 10.75 years.
Sex: 75% male.
Race: Not reported.
Sickle cell disease: Not reported.
Participants appeared to be balanced with respect to baseline characteristics.
Inclusion criteria: Traumatic hyphema.
Exclusion criteria:

  1. More than 48 hours since trauma

  2. Use of anticoagulants

  3. History of risk of clot formation

  4. History of diabetes
Interventions Treatment: Oral aminomethylbenzoic acid 0.5 g plus oral vitamin B1 20 mg 3 times/day, for 6 days. For children, the dosage of aminomethylbenzoic acid was modified to "follow age‐recommended dose"; the vitamin B1 dosage remained the same.
Control: Oral vitamin B1 20 mg 3 times/day, for 6 days.
Treatment for both groups included 0.3% ofloxacin eyedrops 4 times/day, for 6 days.
Outcomes Primary outcome: Risk of secondary hemorrhage, details not reported.
Secondary outcomes: Risk of complications and adverse events.
Notes Poor description of study methods in publication
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Randomized, but method of allocation not reported.
Allocation concealment (selection bias) Unclear risk Method of allocation concealment not reported.
Blinding (performance bias and detection bias) 
 Participants Unclear risk The authors do not state whether masking was used.
Blinding (performance bias and detection bias) 
 Personnel and outcome assessors Unclear risk The authors do not state whether masking was used.
Incomplete outcome data (attrition bias) 
 Primary outcome Low risk No exclusions or loss to follow‐up. All participants were analyzed in the group to which they had been randomly assigned.
Incomplete outcome data (attrition bias) 
 Secondary outcomes Low risk No exclusions or loss to follow‐up. All participants were analyzed in the group to which they had been randomly assigned.
Selective reporting (reporting bias) Unclear risk Study outcomes of interest not clearly stated.
Other bias Low risk No other sources of potential bias were identified.