Study	Reason for exclusion
Amirova 1991	Included non‐traumatic hyphema cases in trial and could not separate outcomes in traumatic hyphema cases; the method of choosing the control group was not mentioned.
Anderson 1971	Not a clinical trial, case reports
Berrios 1995	Review of traumatic hyphema, no original data
Bramsen 1977	Not a clinical trial, used historical controls
Bramsen 1980	Review of previously published studies, no original data
Campana 1969	Not a clinical trial, case reports and experimental studies in rabbits
Cherkasov 1989	Did not include traumatic hyphema cases, all had vitreous hemorrhage.
Crawford 1976	Not a clinical trial, retrospective cohort study
Dralands 1981	Not a clinical trial, used historical controls
Dumitrache 2011	Not a clinical trial, case reports
Gabler 2002	Review of treatment strategies for ocular emergencies, no original data
Gastaldi 1970	Review of treatments for traumatic hyphema, no original data
Ghisolfi 1972	Included non‐traumatic hyphema cases in trial and could not separate outcomes in traumatic hyphema cases
Gilbert 1973	Not a clinical trial, used historical controls
Gillan 1961	Not a clinical trial, used historical controls
Goldberg 1960	Not a clinical trial, cohort study using chart review
Gundorova 1985	Not a clinical trial. There were only 3 participants with post‐traumatic hyphema and no obvious control group was defined.
Guseva 2010	Included non‐traumatic hyphema cases and could not separate outcomes in traumatic hyphema cases; the method of choosing treatment groups was not mentioned.
Heath 1966	Not a clinical trial, case reports
Jrasnov 1986	Not a clinical trial, all participants on same drug therapy, compared those who eventually had surgery vs those who did not.
Kirschner 2012	Summary of review, no original data
Kotas 1990	Not a clinical trial, case report
Krasnov 1971a	There were only 6 participants with post‐traumatic hyphema without surgery or penetrating injuries; participants with different types of glaucoma were classified and treated with glycerin alone or with glycerin and thromboplastin accordingly.
Krasnov 1971b	Not a clinical trial, 2 case series and 1 report of an animal study
Latinovic 1981	Interventional case series, no control group
Li 1997	Included non‐traumatic hyphema cases in trial and could not separate outcomes in traumatic hyphema cases
Li 2009	Not a clinical trial, cohort study
Logai 1974	Not a clinical trial, case series of 74 eyes with hyphema, 28 had non‐penetrating traumatic hyphema
Mathis 1987	Not a clinical trial, case reports
Missotten 1977	Not a clinical trial, used historical controls
Mortensen 1978	Not a clinical trial, used historical controls
Munoz Negrete 1989	Interventional case series, no control group
Murzin 1966	Not a clinical trial, appears to be without a control group, and the author tested 2 different drugs in various combinations for various types of bleeds in the eye, which occurred at various times before the onset of treatment.
Ohrstrom 1972	Not a clinical trial, cohort study
Oksala 1967	Not a clinical trial, cohort study
Pierse 1964	Not a clinical trial, case reports
Pogorel'skii 1966	Not a clinical trial, cohort study comparing people with hemophthalmos treated with chymotrypsin vs people with hemorrhage into the eye cavity treated with resorption therapy
Polychronakos 1967	Not a clinical trial, case reports
Rakusin 1971	Not eligible, surgical interventions
Roberts 2006	Editorial calling for trial of traumatic hyphema to be done, no original data
Romano 1986	Review of corticosteroids for the treatment of traumatic hyphema, no original data
Romashchenko 1985	Groups of patients with bleeds in the eye: group 1 was a mix of post‐traumatic and postoperative hyphemas (no clear group with post‐traumatic hyphemas); the control group was taken from a retrospective study of case notes from 1979 to 1981 and had received an entirely different set of drugs as treatment for their bleeds in the eye.
Rouher 1966	Not a clinical trial, report of 10 cases, only some patients had hyphema
Spoor 1990	Not a clinical trial, cohort study
Stepanov 2002	Not a clinical trial, no control group
Surel 1987	Not a clinical trial, used historical controls
Tartakovskaia 1972	Not a clinical trial, no control group
Travkin 1997	Included non‐traumatic hyphema cases in trial and could not separate outcomes in traumatic hyphema cases
Uusitalo 1988	Not a clinical trial, used historical controls
Volpe 1991	Combined randomized and non‐randomized participants into 1 cohort
Wang 2010	Not related to medical treatments for hyphema, compared satisfaction in 2 groups based on whether or not they had received education on having glaucoma secondary to traumatic hyphema.
Watkins 1974	Not a clinical trial, animal study and case reports
Welsh 1971	Not a clinical trial, case reports
Williams 1993	Not a clinical trial, interventional case series
Williamson 1973	Not a clinical trial, report of 4 cases
Wilson 1990	Not a clinical trial, cohort study
Wright 1964	Included non‐traumatic hyphema cases in trial and could not separate outcomes in traumatic hyphema cases
Yan 2012	Included participants who may have been treated surgically prior to study enrollment
Yasuna 1974	Not a clinical trial, used historical controls
Zhang 2013	Retrospective study comparing routine treatment with or without chymotrypsin for grade III contusive hyphema
Zhang 2014	Compared routine treatment with or without Hexue mingmu tablets for hyphema; method of randomization not reported.
Zhou 1982	Not a clinical trial, groups were selected based on severity of injury
Zobina 1987	Not a clinical trial, case series, no control group
Zobina 1996	Not a clinical trial, description of therapy with observational findings