5. Pyronaridine‐artesunate (PY‐AS) versus other antimalarials: electrocardiogram (ECG) abnormalities.
| Comparator drug | Trial | Pyronaridine‐artesunate | Comparator | ||
| ECG abnormalities | Number of participants | ECG abnormalities | Number of participants | ||
| Artemether‐lumefantrine | Sagara 2018 | 55 | 673 | 99 | 671 |
| Amodiaquine‐artesunate | Sagara 2018 | 34 | 669 | 91 | 668 |
| Chloroquine | Poravuth 2011a | 1 | 228 | 6 | 228 |
| Shin 2011a | 0 | 15 | 1 | 15 | |
| Dihydroartemisinin‐piperaquine or artesunate alone | Nelwan 2015b | 0 | 60 | 1 | 120 |
| Total | 90 | 1645 | 198 | 1702 | |
aP vivax participants only. bPyronaridine alone used as study drug.