NCT01802099.

Methods	RCT
Participants	Adults, ≥ 18 years of age, requiring mechanical ventilation for > 48 hours, treated with a vasoactive drug via a CVC, eligible for nutritional support started within 24 hours after endotracheal intubation (or within 24 hours after ICU admission if intubation occurred before ICU admission)
Interventions	Early EN formula vs PN formula. EN group given EN for 8 days, then supplemental PN if required. PN group given PN for at least 72 hours, then weaned to EN if haemodynamically stable
Outcomes	Mortality (28 days) VAP Bacteraemia CVC‐related complications Urinary tract infections Soft tissue infections Nosocomial infections Bacteriological data Vomiting or regurgitation Diarrhoea Bowel ischaemia Mean caloric intake Volume of liquid feed SOFA scores ICU mortality 90‐day mortality Hospital mortality Mean changes in albumin Prealbumin and C‐reactive protein Liver dysfunction episode ICU length of stay Hospital length of stay Duration of mechanical ventilation Changes in mean bodyweight
Notes	Clinical trials registration ID: NCT0180299 Study terminated early due to Data Safety and Monitoring Board recommendation. Report of results prior to termination not yet published