Fig 2. SmCB1 proteolytic activity induces IL-4 expression in CD4⁺ T cells.

4get IL-4 reporter mice were immunized subcutaneously in the footpad with either PBS, active SmCB1, or inactivated SmCB1 on day 0, 14 and 21. On day 22, the draining popliteal and inguinal nodes were removed and the frequency (A) and total number (B) of IL-4-GFP⁺ CD4⁺ T cells were determined by flow cytometry. n.s., P > 0.05; *, P < 0.05; **, P < 0.01.