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. 2019 Jan 24;12:815–823. doi: 10.2147/OTT.S165647

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© 2019 Wang et al. This work is published and licensed by Dove Medical Press Limited

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Avasimibe treatment led to the inhibition of FoxM1-AKR1C1.

Notes: (A) Cluster of changed genes in epithelial cell differentiation. (B) Cluster of changed genes in PI3K-Akt signaling pathway. (C) U2OS cells were treated with avasimibe, and the protein levels of FoxM1, AKR1C1, PDGFA, and Phospho-ERK were detected by Western blotting. (D) Schematic diagram shows the mechanism underlying avasimibe inhibition of the FoxM1-AKR1C1/PDGFA, and Phospho-ERK signaling pathways.