Deng 2016.

Methods	Randomised, placebo‐controlled trial
Participants	32 people with RLS, renal disease on dialysis at least 1 year, with serum ferritin < 200 ng/mL and transferrin saturation < 20%. Age > 18 was not specified as an inclusion criteria, but mean age was 63.9 (standard deviation 6.5) years
Interventions	Intervention: Iron sucrose, given as a 50 mL injection (containing 100 mg iron sucrose) three times per week for a total of 10 doses Placebo: sodium chloride, given as the same volume and with the same schedule
Outcomes	IRLS, serum iron measurements
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Study was randomised in pairs but method of sequence generation not specified
Allocation concealment (selection bias)	Unclear risk	No mention of allocation concealment; study unblinded
Blinding (performance bias and detection bias) All outcomes	High risk	Unblinded study
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing outcome data
Selective reporting (reporting bias)	Unclear risk	No mention of study protocol registration
Other bias	Low risk	Unclear if participants were allowed to use other RLS medications during the study and whether such use was balanced between groups; note made that dialysis prescription had to remain unchanged