Deng 2016.
Methods | Randomised, placebo‐controlled trial | |
Participants | 32 people with RLS, renal disease on dialysis at least 1 year, with serum ferritin < 200 ng/mL and transferrin saturation < 20%. Age > 18 was not specified as an inclusion criteria, but mean age was 63.9 (standard deviation 6.5) years | |
Interventions | Intervention: Iron sucrose, given as a 50 mL injection (containing 100 mg iron sucrose) three times per week for a total of 10 doses Placebo: sodium chloride, given as the same volume and with the same schedule |
|
Outcomes | IRLS, serum iron measurements | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Study was randomised in pairs but method of sequence generation not specified |
Allocation concealment (selection bias) | Unclear risk | No mention of allocation concealment; study unblinded |
Blinding (performance bias and detection bias) All outcomes | High risk | Unblinded study |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No missing outcome data |
Selective reporting (reporting bias) | Unclear risk | No mention of study protocol registration |
Other bias | Low risk | Unclear if participants were allowed to use other RLS medications during the study and whether such use was balanced between groups; note made that dialysis prescription had to remain unchanged |