Grote 2009.

Methods	Randomised, placebo‐controlled trial
Participants	60 adult men and women meeting all 4 RLS diagnostic criteria who had IRLS scores >= 10 and s‐ferritin < 45 ng/mL, recruited from three separate hospitals (Sweden)
Interventions	Intervention: 200 mg iron sucrose IV (10 mL of 20 mg/mL iron (III) as iron (III)‐hydroxide sucrose complex) given 5 times over 3 weeks Placebo: sodium chloride given with same timing as intervention
Outcomes	IRLS (baseline (BL), week 3, week 7, week 11, month 5, month 8, month 12, with difference at week 11 set as primary outcome), ferritin, ESS
Notes	Funded by pharmaceutical company
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Minimisation method
Allocation concealment (selection bias)	Low risk	Central randomisation
Blinding (performance bias and detection bias) All outcomes	Low risk	Non‐transparent infusion bags and disposables used to obscure treatment condition
Incomplete outcome data (attrition bias) All outcomes	Low risk	Intention‐to‐treat analysis with last observation carried forward
Selective reporting (reporting bias)	Unclear risk	Study protocol registered but registration date appears to be after study completion
Other bias	Low risk	No other risks identified