Fig 5. Admixture of HLA alleles associated with MS.

Ancestry was inferred for MS-associated HLA alleles that passed QC using RFMix. MS-associated alleles were significant at the nominal level (p < 0.05), had imputation score R² > 0.80, and had minor allele frequency greater than 0.005. Other than HLA-B*55:01 in (A) African Americans, HLA-DRB1*15:01, HLA-DRB1*16:02, HLA-DRB1*01:01, HLA-DRB1*14:02, HLA-A*01:01 in (B) Hispanics, and HLA-B*27:05 and HLA-C*03:04 in (C) Asian Americans, HLA alleles associated with MS are cosmopolitan.