Table 4. European ancestry association with MS at regions of the MHC in Asian Americans.
MHC Region | z score | P value | ||
---|---|---|---|---|
DQB1 | -1.60E-2 | 5.98E-2 | -1.67 | 4.80E-2 |
DRB1 | -1.60E-2 | 5.98E-2 | -1.67 | 4.80E-2 |
HLA A | -3.94E-2 | 3.21E-2 | -1.56 | 5.94E-2 |
Class II | -1.67E-2 | 5.35E-2 | -1.52 | 6.39E-2 |
Class III | -7.52E-3 | 5.83E-2 | -1.48 | 7.00E-2 |
DPB1 | -2.38E-2 | 4.32E-2 | -1.43 | 7.69E-2 |
MICB-LST1 | -8.18E-3 | 5.37E-2 | -1.36 | 8.62E-2 |
Class I | -1.90E-2 | 4.07E-2 | -1.33 | 9.24E-2 |
HLA B | -3.69E-4 | 5.28E-2 | -1.14 | 1.27E-1 |
HLA C | -3.69E-4 | 5.27E-2 | -1.14 | 1.27E-1 |
Tests of European ancestry association with MS using test statistic for admixture mapping, sorted by P value. The column represents difference in average local and global European (k) ancestry proportions for cases d. The quantity is defined similarly for controls c. The z score is the admixture mapping test statistic calculated as described in Materials and Methods.