Table 5. Ancestry of HLA alleles associated with MS in African Americans.
| Allele | N | OR | P value | Adj P value | EUR | AFR |
|---|---|---|---|---|---|---|
| HLA-DRB1*15:01 | 512 | 2.00 (1.58–2.55) | 1.26E-8 | 8.83E-7 | 0.64 | 0.36 |
| HLA-DRB1*03:01 | 658 | 1.45 (1.22–1.72) | 2.61E-5 | 1.83E-3 | 0.34 | 0.66 |
| HLA-B*07:02 | 598 | 1.48 (1.23–1.78) | 3.61E-5 | 2.53E-3 | 0.53 | 0.47 |
| HLA-DRB1*15:03 | 881 | 1.37 (1.17–1.59) | 8.11E-5 | 5.68E-3 | 0.00 | 1.00 |
| HLA-DRB1*14:01 | 106 | 0.39 (0.22–0.70) | 1.37E-3 | 9.58E-2 | 0.49 | 0.51 |
| HLA-A*03:01 | 694 | 1.3 (1.10–1.54) | 1.97E-3 | 1.38E-1 | 0.38 | 0.62 |
| HLA-A*02:01 | 914 | 0.8 (0.68–0.94) | 7.88E-3 | 5.51E-1 | 0.48 | 0.52 |
| HLA-C*08:02 | 198 | 1.44 (1.07–1.94) | 1.47E-2 | 1.00E+0 | 0.21 | 0.79 |
| HLA-B*55:01 | 45 | 0.24 (0.07–0.78) | 1.74E-2 | 1.00E+0 | 0.98 | 0.02 |
| HLA-DRB1*13:01 | 476 | 0.76 (0.60–0.96) | 2.09E-2 | 1.00E+0 | 0.20 | 0.80 |
| HLA-C*04:01 | 1704 | 0.87 (0.76–0.98) | 2.35E-2 | 1.00E+0 | 0.13 | 0.87 |
| HLA-C*07:02 | 708 | 1.22 (1.02–1.45) | 2.55E-2 | 1.00E+0 | 0.48 | 0.52 |
| HLA-B*38:01 | 43 | 0.28 (0.09–0.94) | 3.87E-2 | 1.00E+0 | 0.91 | 0.09 |
| HLA-C*03:02 | 95 | 0.57 (0.33–0.98) | 4.30E-2 | 1.00E+0 | 0.00 | 1.00 |
HLA alleles that were nominally associated with MS (p < 0.05) and their ancestry proportions estimated from RFMix. Odds ratio (OR) of association for case-control comparison are also shown along with their 95% confidence interval. All tested HLA alleles passed imputation quality score (R2 > 0.80) and have allele frequencies greater than 0.005. N = number of alleles; EUR = European; AFR = African; Adj P value = Bonferroni adjusted p-value.