Table 6. Ancestry of HLA alleles associated with MS in Hispanics.
| Allele | N | OR | P value | Adj P value | EUR | AMR | AFR |
|---|---|---|---|---|---|---|---|
| HLA-DRB1*15:01 | 534 | 2.45 (1.88–3.19) | 2.59E-11 | 2.00E-9 | 0.96 | 0.02 | 0.02 |
| HLA-DRB1*16:02 | 180 | 1.92 (1.23–2.99) | 4.11E-3 | 3.17E-1 | 0.01 | 0.97 | 0.02 |
| HLA-DRB1*13:01 | 314 | 0.47 (0.27–0.84) | 1.13E-2 | 8.66E-1 | 0.81 | 0.03 | 0.17 |
| HLA-C*04:01 | 1601 | 0.76 (0.61–0.95) | 1.52E-2 | 1.00E+0 | 0.22 | 0.68 | 0.1 |
| HLA-DRB1*01:01 | 395 | 0.54 (0.33–0.89) | 1.65E-2 | 1.00E+0 | 0.96 | 0.01 | 0.03 |
| HLA-B*08:01 | 318 | 1.54 (1.08–2.21) | 1.71E-2 | 1.00E+0 | 0.93 | 0.02 | 0.05 |
| HLA-B*40:02 | 545 | 1.39 (1.05–1.84) | 2.22E-2 | 1.00E+0 | 0.09 | 0.91 | 0.00 |
| HLA-DRB1*14:02 | 454 | 0.60 (0.39–0.94) | 2.49E-2 | 1.00E+0 | 0.03 | 0.96 | 0.01 |
| HLA-C*08:02 | 327 | 1.52 (1.05–2.20) | 2.53E-2 | 1.00E+0 | 0.19 | 0.72 | 0.08 |
| HLA-DRB1*09:01 | 160 | 0.39 (0.17–0.91) | 2.90E-2 | 1.00E+0 | 0.19 | 0.47 | 0.34 |
| HLA-A*01:01 | 521 | 1.40 (1.03–1.91) | 3.29E-2 | 1.00E+0 | 0.97 | 0.02 | 0.00 |
| HLA-C*07:02 | 976 | 1.28 (1.02–1.62) | 3.55E-2 | 1.00E+0 | 0.45 | 0.51 | 0.05 |
| HLA-B*14:01 | 56 | 2.16 (1.03–4.55) | 4.26E-2 | 1.00E+0 | 0.95 | 0.00 | 0.05 |
| HLA-B*81:01 | 47 | 2.38 (1.02–5.54) | 4.44E-2 | 1.00E+0 | 0.09 | 0.09 | 0.83 |
| HLA-B*07:02 | 460 | 1.36 (1.00–1.85) | 4.86E-2 | 1.00E+0 | 0.90 | 0.05 | 0.06 |
HLA alleles that were nominally associated with MS (p < 0.05) and their ancestry proportions estimated from RFMix. Odds ratio (OR) of association for case-control comparison are also shown along with their 95% confidence interval. All tested HLA alleles passed imputation quality score (R2 > 0.80) and had allele frequencies greater than 0.005. N = number of alleles; EUR = European; AMR = American; AFR = African. Adj P value = Bonferroni adjusted p-value.