Table 7. Ancestry of HLA alleles associated with MS in Asian Americans.
| Allele | N | OR | P value | Adj P value | EUR | EAS |
|---|---|---|---|---|---|---|
| HLA-B*27:05 | 50 | 6.74 (1.92–23.66) | 2.92E-3 | 1.34E-1 | 0.98 | 0.02 |
| HLA-DRB1*15:01 | 1228 | 1.88 (1.19–2.99) | 7.26E-3 | 3.34E-1 | 0.07 | 0.93 |
| HLA-C*03:04 | 1687 | 1.69 (1.04–2.76) | 3.43E-2 | 1.00E+0 | 0.04 | 0.96 |
| HLA-DRB1*12:02 | 1139 | 0.32 (0.11–0.94) | 3.75E-2 | 1.00E+0 | 0.00 | 1.00 |
HLA alleles that were nominally associated with MS (p < 0.05) and their ancestry proportions estimated from RFMix. Odds ratio (OR) of association for case-control comparison are also shown along with their 95% confidence interval. All tested HLA alleles passed imputation quality score (R2 > 0.80) and had allele frequencies greater than 0.005. N = number of alleles; EUR = European; EAS = East Asian. Adj P value = Bonferroni adjusted p-value.