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. 2019 Jan;60(1):420–429. doi: 10.1167/iovs.18-24813

Figure 2.

Figure 2

Cecal bacterial microbiome alterations in EAU versus MTB adjuvant alone. (A, B) Alpha diversity measures from cecal contents in EAU versus MTB-immunized versus nonimmunized mice at 1 (day 7) and 2 (day 14) weeks by observed OTUs (A) and Chao1 index (B). (C) Beta diversity as shown by weighted unifrac analysis on a PCoA plot. (D) LefSe analysis showing differentially abundant cecal bacterial strains in IRBP-immunized mice compared to MTB-alone at 1 week. Cladogram showing phylotype differences between MTB-immunized versus IRBP-immunized (EAU) mice at 1 week (at right). (E) LefSe analysis showing differentially abundant cecal bacterial genera in IRBP-immunized mice versus MTB-alone at 2 weeks. Cladogram showing phylotype differences between MTB-immunized versus IRBP-immunized (EAU) mice at 2 weeks (at right). **P < 0.01.