NCT01511666.

Trial name or title	Hyperinvasive Approach in Cardiac Arrest/Hyperinvasive Approach to Out‐of Hospital Cardiac Arrest Using Mechanical Chest Compression Device, Prehospital Intraarrest Cooling, Extracorporeal Life Support and Early Invasive Assessment Compared to Standard of Care. A Randomized Parallel Group Comparative Study. "Prague OHCA Study"
Methods	Prospective randomized multi‐centre clinical study
Participants	Patients with witnessed OHCA without ROSC after a minimum of 5 minutes of ACLS by emergency medical service (EMS) team
Interventions	Intervention group: prehospital mechanical compression device, intra‐arrest cooling and in‐hospital ECLS (LUCAS, Rhinochill, PLS ECMO). Control group: Standard care as per recent guidelines will be provided
Outcomes	Composite endpoint of survival with good neurological outcome (CPC 1‐2)
Starting date	March 2013
Contact information	Jan Belohlavek, MD, PhD Charles University, Czech Republic
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