Table 1.
A list of miRNAs deregulated in camptothecin-treated Jurkat cells. The cloning frequency of miRNAs was calculated as reads per million (RPM) following the removal of the adapter sequences. The miRNAs with a cloning frequency of 10 RPM in all three samples were used in calculations. The fold of expression is presented in a log ratio. JNN: Drug-free control cells; JAN: Annexin V-negative fraction of drug-treated cells; JAP: Annexin V-positive fraction of drug-treated cells.
| Upregulated in JAN | Suppressed in JAN vs JNN | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| miRNA | JAN/JNN | JAP/JNN | JAP/JAN | miRNA | JAN/JNN | JAP/JNN | JAP/JAN | ||||
| hsa-miR-128 | 4.82 | –2.94 | –7.75 | hsa-miR-19b-3p | –1.63 | –4.34 | –2.71 | ||||
| hsa-miR-17-3p | 7.14 | 0.51 | –6.62 | hsa-miR-19a-3p | –1.73 | –4.31 | –2.59 | ||||
| hsa-miR-720 | 1.74 | –3.42 | –5.15 | hsa-miR-17-5p | –1.59 | –3.87 | –2.28 | ||||
| hsa-miR-7-5p | 3.53 | –0.52 | –4.05 | hsa-miR-20b-5p | –1.10 | –3.23 | –2.13 | ||||
| hsa-miR-1268b | 3.79 | –0.26 | –4.05 | hsa-miR-210 | –1.91 | –3.97 | –2.06 | ||||
| hsa-miR-1268a | 3.77 | –0.26 | –4.04 | hsa-miR-374a-5p | –1.09 | –2.93 | –1.84 | ||||
| hsa-miR-25-3p | 3.49 | –0.41 | –3.90 | hsa-miR-320a | –2.57 | –4.29 | –1.72 | ||||
| hsa-let-7b-5p | 1.60 | –2.19 | –3.79 | hsa-miR-29b-3p | –5.01 | –6.44 | –1.43 | ||||
| hsa-miR-324-5p | 1.87 | –1.85 | –3.72 | hsa-let-7d-5p | –1.95 | –3.29 | –1.34 | ||||
| hsa-miR-106b-3p | 2.76 | –0.86 | –3.62 | hsa-miR-185-5p | –1.27 | –2.34 | –1.08 | ||||
| hsa-miR-101-3p | 2.62 | –0.66 | –3.28 | hsa-miR-484 | –1.83 | –2.77 | –0.94 | ||||
| hsa-miR-221-3p | 3.17 | –0.07 | –3.23 | hsa-miR-150-3p | –1.02 | –1.86 | –0.83 | ||||
| hsa-miR-331-3p | 2.85 | –0.36 | –3.21 | hsa-miR-20b-3p | –1.34 | –2.14 | –0.80 | ||||
| hsa-miR-15a-5p | 1.88 | –1.09 | –2.97 | hsa-miR-106a-5p | –2.50 | –3.24 | –0.74 | ||||
| hsa-miR-28-3p | 1.75 | –0.95 | –2.70 | hsa-miR-153 | –1.56 | –2.22 | –0.66 | ||||
| hsa-let-7d-3p | 1.52 | –0.99 | –2.51 | hsa-miR-542-5p | –1.77 | –2.43 | –0.65 | ||||
| hsa-miR-16-2-3p | 1.62 | –0.68 | –2.30 | hsa-miR-1301 | –2.37 | –3.01 | –0.64 | ||||
| hsa-miR-21-5p | 1.63 | –0.63 | –2.26 | hsa-miR-148a-5p | –1.35 | –1.87 | –0.53 | ||||
| hsa-miR-3613-5p | 2.02 | –0.21 | –2.23 | hsa-miR-454-3p | –1.35 | –1.85 | –0.49 | ||||
| hsa-miR-181d | 1.87 | –0.33 | –2.20 | hsa-miR-26b-5p | –3.17 | –3.58 | –0.41 | ||||
| hsa-miR-362-5p | 2.13 | –0.07 | –2.20 | hsa-miR-181b-3p | –1.20 | –1.54 | –0.34 | ||||
| hsa-miR-548d-5p | 1.66 | –0.50 | –2.16 | hsa-miR-191-5p | –4.24 | –4.57 | –0.33 | ||||
| hsa-miR-301a-5p | 1.54 | –0.37 | –1.92 | hsa-miR-301b | –1.86 | –2.17 | –0.31 | ||||
| hsa-miR-186-3p | 1.68 | –0.17 | –1.84 | hsa-miR-20a-5p | –3.54 | –3.83 | –0.30 | ||||
| hsa-miR-1307-3p | 1.08 | –0.63 | –1.71 | hsa-miR-222-3p | –1.69 | –1.93 | –0.24 | ||||
| hsa-miR-671-3p | 1.07 | –0.54 | –1.61 | hsa-miR-30c-1-3p | –2.58 | –2.81 | –0.22 | ||||
| hsa-miR-32-3p | 1.30 | –0.27 | –1.57 | hsa-miR-590-3p | –1.19 | –1.41 | –0.21 | ||||
| hsa-miR-378d | 1.32 | –0.03 | –1.35 | hsa-miR-183-5p | –1.08 | –1.29 | –0.21 | ||||
| hsa-miR-589-5p | 1.01 | –0.30 | –1.31 | hsa-miR-342-5p | –1.13 | –1.30 | –0.17 | ||||
| hsa-miR-4677-3p | 1.13 | –0.16 | –1.28 | hsa-miR-545-5p | –1.03 | –1.19 | –0.17 | ||||
| hsa-miR-548w | 1.35 | 0.09 | –1.25 | hsa-miR-625-3p | –1.34 | –1.51 | –0.16 | ||||
| hsa-miR-378c | 1.14 | –0.09 | –1.23 | hsa-miR-30b-3p | –2.59 | –2.71 | –0.12 | ||||
| hsa-miR-29b-1-5p | 1.06 | 0.00 | –1.06 | hsa-miR-146b-5p | –1.84 | –1.92 | –0.07 | ||||
| hsa-miR-193a-5p | 1.75 | 0.69 | –1.06 | hsa-miR-4454 | –1.13 | –1.19 | –0.06 | ||||
| hsa-miR-424-3p | 1.20 | 0.21 | –0.99 | hsa-miR-503 | –1.61 | –1.65 | –0.04 | ||||
| hsa-miR-1246 | 1.86 | 2.73 | 0.87 | hsa-miR-99b-5p | –1.13 | –1.14 | –0.01 | ||||
| hsa-miR-106a-3p | –1.04 | –1.04 | 0.00 | ||||||||
| hsa-miR-1285-3p | –1.39 | –1.39 | 0.00 | ||||||||
| Equal in JAN vs. JNN | hsa-miR-331-5p | –1.78 | –1.78 | 0.00 | |||||||
| miRNA | JAN/JNN | JAP/JNN | JAP/JAN | hsa-miR-28-5p | –1.12 | –1.08 | 0.03 | ||||
| hsa-miR-92a-1-5p | –0.87 | –4.54 | –3.67 | hsa-miR-19b-1-5p | –2.85 | –2.80 | 0.05 | ||||
| hsa-miR-26a-5p | –0.35 | –3.69 | –3.35 | hsa-miR-1277-3p | –3.02 | –2.97 | 0.05 | ||||
| hsa-miR-18a-5p | –0.41 | –3.62 | –3.21 | hsa-miR-96-5p | –2.39 | –2.34 | 0.05 | ||||
| hsa-miR-301a-3p | 0.86 | –2.17 | –3.03 | hsa-miR-744-3p | –1.24 | –1.17 | 0.07 | ||||
| hsa-miR-125a-5p | 0.69 | –2.26 | –2.94 | hsa-miR-29a-3p | –3.01 | –2.94 | 0.07 | ||||
| hsa-miR-18b-5p | 0.59 | –2.15 | –2.74 | hsa-miR-532-5p | –1.20 | –1.12 | 0.08 | ||||
| hsa-let-7a-5p | 0.33 | –2.18 | –2.52 | hsa-miR-26b-3p | –1.28 | –1.19 | 0.10 | ||||
| hsa-miR-296-3p | –0.01 | –2.48 | –2.47 | hsa-let-7g-3p | –1.98 | –1.88 | 0.11 | ||||
| hsa-miR-27b-3p | 0.71 | –1.74 | –2.45 | hsa-miR-130b-3p | –4.70 | –4.58 | 0.12 | ||||
| hsa-miR-148a-3p | –0.59 | –2.86 | –2.27 | hsa-miR-140-3p | –1.46 | –1.33 | 0.13 | ||||
| hsa-miR-374b-5p | 0.44 | –1.81 | –2.26 | hsa-miR-16-1-3p | –2.84 | –2.69 | 0.15 | ||||
| hsa-miR-92a-3p | 0.53 | –1.68 | –2.21 | hsa-miR-151a-5p | –4.74 | –4.55 | 0.19 | ||||
| hsa-miR-744-5p | 0.46 | –1.68 | –2.14 | hsa-miR-424-5p | –4.79 | –4.59 | 0.20 | ||||
| hsa-miR-150-5p | 0.61 | –1.43 | –2.04 | hsa-miR-223-5p | –1.71 | –1.50 | 0.21 | ||||
| hsa-miR-106b-5p | –0.40 | –2.38 | –1.98 | hsa-miR-30b-5p | –2.58 | –2.34 | 0.24 | ||||
| hsa-miR-191-3p | –0.03 | –1.99 | –1.96 | hsa-let-7i-3p | –2.75 | –2.49 | 0.25 | ||||
| hsa-miR-223-3p | 0.50 | –1.42 | –1.92 | hsa-miR-197-3p | –2.08 | –1.80 | 0.28 | ||||
| hsa-miR-18a-3p | –0.35 | –2.11 | –1.76 | hsa-let-7i-5p | –1.92 | –1.62 | 0.30 | ||||
| hsa-miR-92b-3p | 0.20 | –1.54 | –1.75 | hsa-miR-30d-3p | –1.37 | –1.07 | 0.30 | ||||
| hsa-miR-29c-3p | –0.66 | –2.41 | –1.74 | hsa-miR-1277-5p | –2.22 | –1.88 | 0.34 | ||||
| hsa-miR-181a-3p | –0.36 | –1.89 | –1.52 | hsa-miR-194-5p | –2.13 | –1.76 | 0.38 | ||||
| hsa-let-7e-5p | –0.72 | –2.24 | –1.52 | hsa-miR-627 | –2.09 | –1.72 | 0.38 | ||||
| hsa-miR-219-1-3p | 0.53 | –0.93 | –1.46 | hsa-miR-200c-3p | –2.41 | –1.96 | 0.45 | ||||
| hsa-miR-27a-3p | –0.14 | –1.59 | –1.45 | hsa-miR-500a-5p | –1.05 | –0.57 | 0.48 | ||||
| hsa-let-7c | 0.22 | –1.21 | –1.43 | hsa-miR-93-3p | –1.42 | –0.90 | 0.52 | ||||
| hsa-miR-98 | –0.21 | –1.63 | –1.42 | hsa-miR-146a-5p | –3.25 | –2.72 | 0.53 | ||||
| hsa-miR-942 | 0.24 | –1.17 | –1.41 | hsa-miR-320b | –1.52 | –0.94 | 0.57 | ||||
| hsa-miR-7-1-3p | 0.12 | –1.25 | –1.38 | hsa-miR-9-3p | –1.39 | –0.73 | 0.66 | ||||
| hsa-let-7f-5p | 0.10 | –1.19 | –1.29 | hsa-miR-374a-3p | –2.08 | –1.42 | 0.66 | ||||
| hsa-miR-181a-2-3p | 0.31 | –0.98 | –1.28 | hsa-miR-320c | –1.59 | –0.88 | 0.71 | ||||
| hsa-miR-652-3p | 0.44 | –0.78 | –1.22 | hsa-miR-450b-5p | –1.78 | –1.04 | 0.74 | ||||
| hsa-miR-548b-5p | 0.90 | –0.31 | –1.21 | hsa-miR-320d | –1.04 | –0.24 | 0.79 | ||||
| hsa-miR-9-5p | 0.57 | –0.61 | –1.18 | hsa-miR-542-3p | –1.44 | –0.62 | 0.83 | ||||
| hsa-miR-93-5p | 0.09 | –1.08 | –1.17 | hsa-miR-629-3p | –1.24 | –0.38 | 0.86 | ||||
| hsa-miR-760 | 0.81 | –0.33 | –1.14 | hsa-miR-148b-3p | –3.28 | –2.36 | 0.92 | ||||
| hsa-miR-184 | 0.96 | –0.15 | –1.12 | hsa-miR-340-3p | –1.36 | –0.44 | 0.93 | ||||
| hsa-miR-151a-3p | –0.30 | –1.32 | –1.01 | hsa-miR-339-5p | –1.34 | –0.27 | 1.07 | ||||
| hsa-miR-95 | 0.01 | –1.00 | –1.01 | hsa-miR-345-5p | –1.41 | –0.30 | 1.11 | ||||
| hsa-miR-152 | 0.12 | –0.88 | –1.01 | hsa-miR-342-3p | –2.72 | –1.60 | 1.11 | ||||
| hsa-miR-501-3p | –0.40 | –1.26 | –0.86 | hsa-miR-126-3p | –1.96 | –0.78 | 1.18 | ||||
| hsa-miR-27b-5p | –0.29 | –1.07 | –0.78 | hsa-miR-193b-3p | –2.05 | –0.82 | 1.23 | ||||
| hsa-miR-15b-3p | –0.55 | –1.33 | –0.77 | hsa-miR-363-3p | –2.82 | –1.55 | 1.27 | ||||
| hsa-miR-30e-3p | –0.40 | –1.13 | –0.73 | hsa-miR-361-5p | –6.52 | –5.24 | 1.28 | ||||
| hsa-miR-203 | –0.36 | –1.04 | –0.69 | hsa-miR-126-5p | –2.77 | –1.42 | 1.36 | ||||
| hsa-miR-340-5p | –0.82 | –1.34 | –0.52 | hsa-miR-769-5p | –3.28 | –1.87 | 1.41 | ||||
| hsa-miR-196a-5p | –0.99 | –1.39 | –0.40 | hsa-miR-140-5p | –6.36 | –4.74 | 1.61 | ||||
| hsa-miR-625-5p | –0.88 | –1.19 | –0.31 | hsa-miR-30c-5p | –4.80 | –2.90 | 1.90 | ||||
| hsa-miR-580 | –0.85 | –1.13 | –0.29 | hsa-miR-455-3p | –1.37 | 0.66 | 2.03 | ||||
| hsa-miR-454-5p | –0.93 | –1.01 | –0.08 | hsa-let-7g-5p | –6.14 | –3.78 | 2.37 | ||||
| hsa-miR-1292 | –1.00 | –1.02 | –0.02 | hsa-miR-186-5p | –5.45 | –2.80 | 2.65 | ||||
| hsa-miR-1248 | 0.06 | 1.03 | 0.97 | hsa-miR-24-3p | –3.48 | –0.81 | 2.67 | ||||
| hsa-miR-181a-5p | –0.81 | 0.31 | 1.13 | hsa-miR-142-5p | –6.58 | –3.89 | 2.70 | ||||
| hsa-miR-32-5p | –3.12 | –0.11 | 3.01 | ||||||||
| hsa-miR-142-3p | –4.60 | –1.08 | 3.52 | ||||||||
| hsa-miR-766-3p | –4.79 | –1.05 | 3.74 | ||||||||
| hsa-miR-425-5p | –2.48 | 1.74 | 4.22 | ||||||||