. 2016 Nov 16;4(3):374–382. doi: 10.1002/mdc3.12435

Table 1.

Baseline characteristics of the study sample

Characteristics	Participants included	Participants not included	P‐ value for difference
Demographics	n = 310	n = 193
Age (SD), years	63.3 (8.4)	69.5 (8.1)	<0.001^a
Male sex, No. (%)	173 (55.8)	111 (57.5)	0.80^b
MMSE score, mean (SD)	28.4 (1.5)	27.7 (1.8)	0.005^a
Cognitive index, mean (SD)	0.24 (0.74)	−0.42 (0.67)^c	<0.001^a
Barthel index, mean (SD)	19.8 (0.5)	19.5 (1.2)	0.002^a
Gait characteristics	n = 310	n = 189 ^d
Gait speed, mean (SD), m/s	1.37 (0.22)	1.13 (0.29)	<0.001^a
Gait impairment (gait speed <1.0 m/s), No. (%)	18 (5.8)	52 (27.5)	<0.001^b
Imaging measures ^d	n = 310	n = 192^e
WMH volume, median (IQR), mL	5.1 (2.9–12.0)	13.3 (5.9–25.5)	<0.001^a
Lacunes, presence, No. (%)	56 (18.1)	78 (40.6)	<0.001^b
Microbleeds, presence^f, No. (%)	43 (14.0)	38 (19.9)	0.82^b
WM volume, mean (SD), mL	472.9 (37.9)	450.6 (50.3)	0.02^a
GM volume, mean (SD), mL	628.4 (46.9)	596.0 (50.4)	<0.001^a
WM global FA^g, mean (SD)	0.33 (0.02)	0.32 (0.02)	0.007^a
WM global MD^g, mean (SD), x10^‐3 mm²/s	0.88 (0.04)	0.91 (0.04)	0.008^a

FA, fractional anisotropy; GM, gray matter; IQR , interquartile range; MD, mean diffusivity; MMSE, Mini Mental State Examination; WM, white matter; WMH, WM hyperintensity

Age and sex adjusted using ANCOVA.

Age and sex adjusted using logistic regression.

1 participant was excluded because of missing cognitive data.

4 participants had missing values of baseline gait speed.

Brain volumes are represented normalized to the total intracranial volume.

1 participants was excluded because of imaging artifacts

Respectively 3 (in group included in analysis) and 1 participant(s)(in group not included in analysis) were excluded because of missing values of baseline microbleeds.

Respectively 2 (in group included in analysis) and 1 participant(s) (in group not included in analysis) were excluded because of baseline DTI artifacts.