Table 4.

Relation between baseline imaging measures and the risk of incident gait impairment at follow‐up

Baseline imaging characteristics (n = 292)a	Odds ratio (95% CI) for incident gait impairmentb (n = 48)	P‐value
WMH volume, per SD	1.35 (0.93–1.96)c	0.12
Lacunes, presence	0.90 (0.33–2.48)c	0.84
Microbleeds, presenced	1.55 (0.57–4.24)c	0.39
WM volume, per SD	0.98 (0.63–1.51)c	0.92
GM volume, per SD	0.89 (0.52–1.53)e	0.68
WM global FA, per SDf	0.98 (0.58–1.23)c , e	0.95
WM global MD, per SDf	0.98 (0.51–1.88)c , e	0.94

FA, fractional anisotropy; GM, gray matter; MD, mean diffusivity (*10^‐4mm²/s); per SD, odds ratios per standard deviation difference from the mean; WM, white matter; WMH, WM hyperintensity.

All covariates are adjusted for time between baseline and follow‐up assessment and the following baseline covariates: age, sex, height, gait speed, cognitive index .

^a18 participants with baseline gait speed impairment were excluded from this analysis.

^bDefined as a gait speed <1.0 m/s at follow‐up.

^cAdjusted in addition for gray matter volume.

^d3 participants were excluded because of missing values of microbleeds at baseline.

^eAdjusted in addition for SVD markers (WMH volume, number of lacunes and microbleeds and WM volume).

^f2 participants were excluded for DTI analyses because of baseline DTI artifacts.