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. Author manuscript; available in PMC: 2019 Mar 7.
Published in final edited form as: Genet Med. 2018 Jul 27;21(3):705–717. doi: 10.1038/s41436-018-0106-5

Figure 3. Metabolite profiling identifies pathogenic fumarate hydratase (FH) mutations previously classified as VUS.

Figure 3.

Sanger sequencing traces of leukocyte (germline) and tumor DNA from patient #10 (A), #11 (B), and #12 (C). D. Immunohistochemical staining for FH of normal adrenal, FH-wildtype and FH-mutated PPGL tissue from patient #10 and #11; 400x magnification.