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. Author manuscript; available in PMC: 2019 Jan 30.
Published in final edited form as: JAMA Psychiatry. 2016 May 1;73(5):506–514. doi: 10.1001/jamapsychiatry.2016.0144

Figure 3. Genotype-Dependent Differentially Methylated Positions in Psychiatric Genomics Consortium Schizophrenia-Associated Locus.

Figure 3.

A, Psychiatric Genomics Consortium Genome-Wide Association Study locus (region 11) with an overlapping schizophrenia (SZ)-associated CpG. Dashed lines indicate single-nucleotide polymorphism–CpG cisregulation between the 2 SZ–single-nucleotide polymorphisms and locus cg25647583. B, Methylation differences between SZ cases and controls at locus cg25647583. C, Association between DNA methylation and genotype. In the Psychiatric Genomics Consortium Genome-Wide Association Study , the A allele is the risk allele (odds ratio = 1.0662). D, Association between genotype and SZ phenotype. The risk allele has increased frequency in our SZ cases. E, β coefficient estimate of the dependence of genotype on SZ phenotype, before and after adjusting for methylation. Error bars represent the 95% CIs for the estimate of β.