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. 2019 Jan 30;5(1):eaav1848. doi: 10.1126/sciadv.aav1848

Fig. 2. Mitochondria-encoded genes affect heat and cold tolerance.

Fig. 2

(A) Hybrids with S. cerevisiae (sc) and S. uvarum (su) mtDNA differ in high- and low-temperature growth. Growth is after 5 days (22° and 37°C) or 124 days (4°C). (B) Recombinant strains (rows) derived from mutant crosses (left) are clustered by genotype (middle). Wild-type S. cerevisiae (wt_sc) and S. uvarum (wt_su) mitotypes are at the bottom and top, respectively. Allele identity is shown for 12,574 orthologous single-nucleotide markers (sc and sc-90, S. cerevisiae; su and su-90, S. uvarum; mixed, heterozygous or chimeric; white, no data) in the S. cerevisiae gene order (bottom). Right: 37°C growth is the average size of nonpetite colonies on glycerol plates. Far right: The presence of 4°C glycerol growth is indicated by solid squares. (C) Effect size of S. cerevisiae alleles on 37°C growth on glycerol, with error bars representing 95% confidence intervals. The y axis is scaled to the phenotype of wild-type S. uvarum and S. cerevisiae mitotype (horizontal lines). Transfer RNAs (tRNAs) are labeled by their single-letter amino acid code and a black bar. Blue dashed lines indicate genome positions of S. uvarum genes compared to S. cerevisiae.