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. 2018 Feb 1;16(2):769–775. doi: 10.1016/j.jgeb.2018.01.003

Fig. 2.

Fig. 2

Tertiary structural models of SLC22A2 rs316019 protein variants. A, B and C. Models of SLC22A2 with Alanine at position 270. D, E and F. Models of SLC22A2 with Serine at position 270. A single amino acid alteration at position 270 causes a global conformational change in SLC22A2. As an example, distances of Leu 488 from Pro 54 and Ala/Ser 270 are shown in figure C and F. Red lines represent the distance between selected amino acid residues in Angstrom (Å). Solid arrows (matched colour) denote reference points to compare structures. G and H. Ramachandran plots of SLC22A2 rs316019 protein variants.